A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Ten millennia of hepatitis B virus evolution
Tekijät: Kocher Arthur, Papac Luka, Barquera Rodrigo, Key Felix M., Spyrou Maria A., Hübler Ron, Rohrlach Adam B., Aron Franziska, Stahl Raphaela, Wissgott Antje, Van Bömmel Florian, Pfefferkorn Maria, Mittnik Alissa, Villalba-Mouco Vanessa, Neumann Gunnar U., Rivollat Maïté, Van De Loosdrecht Marieke S., Majander Kerttu, Tukhbatova Rezeda I., Musralina Lyazzat, Ghalichi Ayshin, Penske Sandra, Sabin Susanna, Michel Megan, Gretzinger Joscha, Nelson Elizabeth A., Ferraz Tiago, Nägele Kathrin, Parker Cody, Keller Marcel, Guevara Evelyn K., Feldman Michal, Eisenmann Stefanie, Skourtanioti Eirini, Giffin Karen, Gnecchi-Ruscone Guido Alberto, Friederich Susanne, Schimment Vittoria, Khartanovich Ivalery, Karapetian Marina K., Chaplygin Mikhail S., Kufterin Vladimir V., Khokhlov Aleksandr A., Chizhevsky Andrey A., Stashenkov Dmitry A., Kochkina Anna F., Tejedor-Rodríguez Cristina, De Lagrán Íñigo García-Martínez, Arcusa-Magallón Héctor, Garrido-Pena Rafael, Royo-Guillén José Ignacio, Nováček Jan, Rottier Stéphane, Kacki Sacha, Saintot Sylvie, Kaverzneva Elena, Belinskiy Andrej B., Velemínský Petr, Limburský Petr, Kostka Michal, Loe Louise, Popescu Elizabeth, Clarke Rachel, Lyons Alice, Mortimer Richard, Sajantila Antti, De Armas Yadira Chinique, Godoy Silvia Teresita Hernandez, Hernández-Zaragoza Diana I., Pearson Jessica, Binder Didier, Lefranc Philippe, Kantorovich Anatoly R., Maslov Vladimir E., Lai Luca, Zoledziewska Magdalena, Beckett Jessica F., Langová Michaela, Danielisová Alžběta, Ingman Tara, Atiénzar Gabriel García, Ibáñez Maria Paz De Miguel, Romero Alejandro, Sperduti Alessandra, Beckett Sophie, Salter Susannah J., Zilivinskaya Emma D., Vasil’ev Dmitry V., Von Heyking Kristin, Burger Richard L., Salazar Lucy C., Amkreutz Luc, Navruzbekov Masnav, Rosenstock Eva, Alonso-Fernández Carmen, Slavchev Vladimir, Kalmykov Alexey A., Atabiev Biaslan Ch., Batieva Elena, Calmet Micaela Alvarez, Llamas Bastien, Schultz Michael, Kraus Raiko, Jiménez-Echevarría Javier, Francken Michael, Shnaider Svetlana, De Knijff Peter, Altena Eveline, Van De Vijver Katrien, Fehrenschmitz Lars, Tung Tiffiny A., Lösch Sandra, Dobrovolskaya Maria, Makarov Nikolaj, Read Chris, Van Twest Melanie, Sagona Claudia, Ramsl Peter C., Akar Murat, Yener K. Aslihan, Ballestero Eduardo Carmona, Cucca Francesco, Mazzarello Vittorio, Utrilla Pilar, Rademaker Kurt, Fernández-Domínguez Eva, Baird Douglas, Semal Patrick, Márquez-Morfín Lourdes, Roksandic Mirjana, Steiner Hubert, Salazar-García Domingo Carlos, Shishlina Natalia, Erdal Yilmaz Selim, Hallgren Fredrik, Boyadzhiev Yavor, Boyadzhiev Kamen, Küssner Mario, Sayer Duncan, Onkamo Päivi, Skeates Robin, Rojo-Guerra Manuel, Buzhilova Alexandra, Khussainova Elmira, Djansugurova Leyla B., Beisenov Arman Z., Samashev Zainolla, Massy Ken, Mannino Marcello, Moiseyev Vyacheslav, Mannermaa Kristiina, Balanovsky Oleg, Deguillou Marie-France, Reinhold Sabine, Hansen Svend, Kitov Egor P., Dobeš Miroslav, Ernée Michal, Meller Harald, Alt Kurt W., Prüfer Kay, Warinner Christina, Schiffels Stephan, Stockhammer Philipp W., Bos Kirsten, Posth Cosimo, Herbig Alexander, Haak Wolfgang, Krause Johannes, Kühnert Denise
Kustantaja: AMER ASSOC ADVANCEMENT SCIENCE
Julkaisuvuosi: 2021
Journal: Science
Tietokannassa oleva lehden nimi: SCIENCE
Lehden akronyymi: SCIENCE
Vuosikerta: 374
Numero: 6564
Aloitussivu: 182
Lopetussivu: 188
Sivujen määrä: 89
ISSN: 0036-8075
DOI: https://doi.org/10.1126/science.abi5658
Verkko-osoite: https://doi.org/10.1126/science.abi5658
Rinnakkaistallenteen osoite: https://dspace.lib.cranfield.ac.uk/bitstream/handle/1826/17264/Ten_millennia_of_hepatitis_B_virus_evolution-2021.pdf;jsessionid=364D31FEB1C52FCC1E8F4E63FA322DA4?sequence=1
Hepatitis B virus (HBV) has been infecting humans for millennia and remains a global health problem, but its past diversity and dispersal routes are largely unknown. We generated HBV genomic data from 137 Eurasians and Native Americans dated between similar to 10,500 and similar to 400 years ago. We date the most recent common ancestor of all HBV lineages to between similar to 20,000 and 12,000 years ago, with the virus present in European and South American hunter-gatherers during the early Holocene. After the European Neolithic transition, Mesolithic HBV strains were replaced by a lineage likely disseminated by early farmers that prevailed throughout western Eurasia for similar to 4000 years, declining around the end of the 2nd millennium BCE. The only remnant of this prehistoric HBV diversity is the rare genotype G, which appears to have reemerged during the HIV pandemic.
